NATIONAL UNIVERSITY OF SAN LUIS / Faculty of Chemistry, Biochemistry and Pharmacy
. A noninvasive tool, rapid, sensitive and automated in the serological diagnosis of the disease gliadin, a vegetable protein some cereals in the diet. ") '> Celiac was developed by researchers at San Luis. This is a microfluidic device that quantifies immune antibodies IgG anti-gliadin sensitive indicators of disease. The new method, which obtains results in just 25 minutes, was published on the cover of the prestigious scientific journal Analytical and Bioanalytical Chemistry ".
Researchers at the University of San Luis developed an innovative new tool in the serological diagnosis of celiac disease. The development requires a minimum analysis time and smaller sample volumes, which is very important in elderly patients, infants and children.The Celiac disease is caused by proteins in the gluten in certain grains, affecting the small intestine of genetically susceptible individuals. It is an autoimmune disease because the body responds to an external agent, gluten, and there is a harm to himself. One in every 250 people suffers. This disease causes intestinal atrophy and also other symptoms, and a consequent loss of quality of life. The only effective treatment is the elimination of gluten proteins in the diet of the patient but, at present, new strategies are investigated biochemical terapéuticas.La Sirley Pereira, a fellow of CONICET and member of research project miniaturized analytical systems and development of chemical and biochemical sensors. Nanochemistry ", directed by Dr. Julio Raba of San Luis Institute of Chemistry, INQUISAL, InfoUniversidades told that in order to reach the diagnosis of this disease are used invasive methods such as endoscopy with biopsy, and other noninvasive techniques such as serological that detect the presence of antibodies. Among the latter, also called immunoglobulins (Ig), the type-specific IgG anti-gliadin. The traditional serological tests require the use of larger volumes of serum and reagents, and results obtained in about two hours. The device developed by researchers is an immuno-sensor coupled to a microfluidic flow injection and electrochemical detection that allows quantification of IgG antibody-anti-gliadin. From this development could be drastically reduced volumes of patient serum samples, reagents and time required, given that in just 25 minutes can be carried out the quantitative determination of IgG antibodies anti-gliadin. Silvinachaves
Universidad Nacional de San Luis
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